Posaconazole enhances the activity of amphotericin B against Aspergillus hyphae in vitro.
نویسندگان
چکیده
The MICs and fractional inhibitory concentrations of posaconazole (POS) and voriconazole (VRZ), alone and in combination with amphotericin B (AMB), for the conidia and hyphae of 100 Aspergillus isolates were evaluated. POS-AMB had more synergistic activity against hyphae (75% of isolates) than VRZ-AMB (37%) and significantly more synergistic activity against hyphae than against conidia (12%).
منابع مشابه
Posaconazole enhances the activity of amphotericin B against hyphae of zygomycetes in vitro.
The in vitro activity of posaconazole plus amphotericin B against conidia and hyphae of 30 clinical zygomycetes was investigated. The combination of posaconazole with amphotericin B was found to be significantly more synergistic (40%) against hyphae (P < 0.05) than against conidia (10%). Antagonism was not observed.
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ورودعنوان ژورنال:
- Antimicrobial agents and chemotherapy
دوره 51 2 شماره
صفحات -
تاریخ انتشار 2007